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KMID : 1237720100430010064
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Anatomy & Cell Biology
2010 Volume.43 No. 1 p.64 ~ p.71
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Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebellum of the nNOS knock-out(-/-) mice
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Lee Jae-Chul
Chung Yoon-Hee
Joo Kyeung-Min
Cha Choong-Ik
Cho Yu-Jin
Kim Jan-Di
Kim Na-Hee
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Abstract
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Nitric Oxide (NO) actively participates in the regulation of neuronal intracellular Ca2+ levels by modulating the activity of various channels and receptors. To test the possibility that modulation of Ca2+ buffer protein expression level by NO participates in this regulatory effect, we examined expression of calbindin-D28k, calretinin, and parvalbumin in the cerebellum of neuronal NO synthase knock-out (nNOS(-/-)) mice using immunohistochemistry. We observed that in the cerebellar cortex of the nNOS(-/-) mice, expression of calbindin-D28k and parvalbumin were significantly increased while expression of calretinin was significantly decreased. These results suggest another mechanism by which NO can participate in the regulation of Ca2+ homeostasis.
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KEYWORD
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Calbindin-D28k, calretinin, parvalbumin, cerebellum, neuronal nitric oxide synthase (nNOS) knock-out (-/-) mice
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